RS 17053 hydrochloride

Research use only, not for human use.

RS 17053 hydrochloride is an effective and selective antagonist of α1A-adrenergic receptor with pA2 of 9.8 in functional assays and pKi of 9.1 in the native cell membrane.

RS 17053 hydrochloride is an effective and selective antagonist of α1A-adrenergic receptor with pA2 of 9.8 in functional assays and pKi of 9.1 in the native cell membrane.(In Vitro):RS 17053 hydrochloride antagonizes responses to NE only at high concentrations in isolated smooth muscle preparations from human LUT tissues. RS 17053 hydrochloride displays a high affinity for the α1A-adrenoceptor (pKi and pA2 estimates of 9.1-9.9) and a 30-100-fold selectivity over the α1 B and the α1 D-adrenoceptor subtypes (pKi and pA2 estimates of 7.7-7.8) in several tissues from rat and cloned adrenoceptors .(In Vivo):RS 17053 hydrochloride has a rapid onset of action and a duration of action exceeding 60 min. RS-17053 (10 mg/kg ) significantly suppresses food intake. RS 17053 hydrochloride pretreatment obviously alters food intake .

RS-17053

Others

Other Targets

Proton pump

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169505-93-5

449.4

C24H30Cl2N2O2

>98% (HPLC)

——

Cl.CC(C)(Cc1c[nH]c2ccc(Cl)cc12)NCCOc1ccccc1OCC1CC1

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(-20℃)

With Ice Pack

≥ 2 years